open-access
25+ Million Readerbase Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles
image image image image
Google Scholar citation report
Citations : 17406

Systematic Reviews in Pharmacy received 17406 citations as per google scholar report

Flyer image
Systematic Reviews in Pharmacy peer review process verified at publons
Flyer image

Indexed In

Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat

Abstract

Alaa Kadhum Mosa, Basem I. Mohammad Al-Shibani, Mohammed A. Abdulhussein, Najah R. Hadi, Hyder Qassam, Yasmeen Ali Hussin

Acute kidney injury (AKI) with all advances in nursing measures and therapeutic strategies, such as kidney transplantation and dialysis, mortality rate of patients with AKI is very high in past 30 years. Despite the path physiology of IRI is not totally understood, several critical mechanisms leading in kidney failure have been demonstrated. In ischemic kidney and successive of generation of reactive oxygen species (ROS), re-oxygenation at reperfusion phase activate a cascade of destroying cellular responses causing to cell death, inflammation, and acute kidney failure. Sacubitrilate is neprilysininhibitor attenuated renal injury possibly through its anti-inflammatory and antioxidant effects. The main objective of the present paper is to study the Nephroprotective potential effect of Sacubitrilate in RIRI. Renal IRI causes significant (p<0.05) increase in tissue level of IL-1β, NGAL, f2- isoprostane, TLR-4 and NF-KB p65 and serum urea, creatinine. Pretreatment with, Sacubitrilate cause significant (p<0.05) decrease in tissue level of IL-1β, NF-KB p65, TLR-4, NGAL, f2- isoprostane, and serum urea, creatinine. Also cause significant reversal of tissue damage when compared with IRI group. Pretreatment with Sacubitrilate significantly decreases renal ischemia reperfusion injury in the rat via their pleiotropic effects as antioxidant, anti-inflammatory and anti- apoptotic activity.

How to Cite this Article
Pubmed Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP. 2019; 10(1): 194-205. doi:10.5530/srp.2019.1.35

Web Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. http://www.sysrevpharm.org/?mno=302644973 [Access: March 29, 2021]. doi:10.5530/srp.2019.1.35

AMA (American Medical Association) Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP. 2019; 10(1): 194-205. doi:10.5530/srp.2019.1.35


Vancouver/ICMJE Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP. (2019), [cited March 29, 2021]; 10(1): 194-205. doi:10.5530/srp.2019.1.35


Harvard Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin (2019) Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP, 10 (1), 194-205. doi:10.5530/srp.2019.1.35


Turabian Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. 2019. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. Systematic Reviews in Pharmacy, 10 (1), 194-205. doi:10.5530/srp.2019.1.35


Chicago Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. "Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat." Systematic Reviews in Pharmacy 10 (2019), 194-205. doi:10.5530/srp.2019.1.35


MLA (The Modern Language Association) Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. "Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat." Systematic Reviews in Pharmacy 10.1 (2019), 194-205. Print. doi:10.5530/srp.2019.1.35


APA (American Psychological Association) Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin (2019) Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. Systematic Reviews in Pharmacy, 10 (1), 194-205. doi:10.5530/srp.2019.1.35

ARTICLE TOOLS
ARTICLE TOOLS
Submit Article
Login
Register
Scan Code
Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3