New Mode for the Determination of Ketotifen Fumarate Using Low Pressure Mercury Lamp via Continuous Flow Injection Analysis

Abstract

Marwah A. Kadhim Al-banaa

The method was based on the quenched of continuous fluorescence of fluorescence dye (N-(4-Aryl diazenyl-p-phenol-1,8-naphthal imide) that were used for determination of ketotifen fumarate. A comprehensive detailed study was carried out by ISNAG-fluorimeter CFIA that capable of measuring fluorescence emitted from fluorescent molecules that be excited by low mercury lamps. The linearity range, r,r2,R2% and limit of detection were : 0.01-10mmol.L-1 , 0.9837 ,0.9676 , 96.76 and 0.425 µg/125µL.Pure and pharmaceutical formulation of mentioned drug was analyzed successfully in this work . A comparison was made between the official quoted value and the practically found values for the three kinds of drug by individual t-test. Individual t-test reveals that there was no significant difference between both means (quoted value with calculated t-value) from developed method.