Abstract

Abhishek Yekkaladev46372 and Koppala RVS Chaitanya46373*

The current discussion focuses on Selenicereus undatus pharmacological effects on various physiological systems. This plant contains high amount of polyphenols thus showing antioxidant activity, influences the p-450 enzyme mechanism either by inhibiting or inducing the metabolic activity of enzymes thus, used for the treatment of hepatotoxicity. Also, Selenicereus undatus is known for its radical scavenging activity due to the presence of phenolic content. Onitin and luteolin isolated from the methanolic extract of Selenicereus undatus showed superoxide scavenging effects and DPPH free radical scavenging activity hence can also be used in cancer treatment. The antioxidant activity and phenolic composition of three different extracts (ethanol, n-butanol and water) of Selenicereus undatus were investigated by measuring the total reducing power expressed by Ascorbate Equivalent Antioxidant Capacity-AEAC, inhibition of lipid peroxidation, and free Radical Scavenging Capacity (RSC) towards 2,2-diphenyl-1-picrylhydrazyl (DPPH radical) and Nitric Oxide (NO).The influence of different extracts during lipid peroxidation of sunflower oil induced by the lipophilic azo-initiator 4,4’-azobis(4-cyanovaleric acid) and soybean phosphatidylcholine liposomes induced by the hydrophilic azo-initiator 2,2’-azobis(2-amidinopropane) dihydrochloride was investigated in this study. Hepatoprotective activity-guided fractionation of the methanol extract of Selenicereus undatus showed that Onitin and luteolin possessed Hepatoprotective activities on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. This plant also possesses sedative and anticonvulsant activity. The hydro alcoholic extract of stem from Selenicereus undatus shows antinociceptive and anti-inflammatory effects. Studies say that Selenicereus undatus can also produce a diuretic effect. The extract of Selenicereus undatus produced a dose-dependent inhibition of thrombin and ADP-induced platelet aggregation with in fact proofs that plant has many pharmacological activities.