open-access
25+ Million Readerbase Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles
image image image image
Google Scholar citation report
Citations : 17406

Systematic Reviews in Pharmacy received 17406 citations as per google scholar report

Flyer image
Systematic Reviews in Pharmacy peer review process verified at publons
Flyer image

Indexed In

Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease

Abstract

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova

Introduction: This study was carried out in the direction of personalized medicine, based on identifying the genetic characteristics of patients, which can affect the pathogenesis of the disease and the effectiveness of pharmacotherapy.
Research tasks: To study of the polymorphism of the cytochrome CYP2C9*2 C430T gene in patients with stable angina pectoris and to evaluate the significance of this factor in pathogenesis of the disease.
Material and Methods: A study of 90 patients with stable angina pectoris was performed. The polymerase chain reaction was used to determine the gene polymorphisms of cytochrome CYP2C9*2 C430T. The condition of DNA was studied by the method of DNA comet assay.
Results and Discussion: The presence of gene polymorphisms by the alleles CYP2C9*2 C430T was found. They revealed a more severe clinical condition of patients with pathological genes by the alleles CYP2C9*2 C430T (CT genotype) in comparison with patients with normal genotype for this allele (CC): a higher functional class of angina pectoris, overweight, blood hypercoagulability, an increased level of personal anxiety and greater DNA damage.
Conclusion: polymorphism of the cytochrome CYP2C9*2 C430T gene is essential in the pathogenesis of angina pectoris: in patients with the pathological genotype of cytochrome CYP2C9*2 C430T gene there were revealed more severe clinical condition.

How to Cite this Article
Pubmed Style

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova. Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease. SRP. 2020; 11(6): 16-20. doi:10.31838/srp.2020.6.04

Web Style

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova. Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease. http://www.sysrevpharm.org/?mno=111898 [Access: March 29, 2021]. doi:10.31838/srp.2020.6.04

AMA (American Medical Association) Style

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova. Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease. SRP. 2020; 11(6): 16-20. doi:10.31838/srp.2020.6.04


Vancouver/ICMJE Style

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova. Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease. SRP. (2020), [cited March 29, 2021]; 11(6): 16-20. doi:10.31838/srp.2020.6.04


Harvard Style

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova (2020) Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease. SRP, 11 (6), 16-20. doi:10.31838/srp.2020.6.04


Turabian Style

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova. 2020. Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease. Systematic Reviews in Pharmacy, 11 (6), 16-20. doi:10.31838/srp.2020.6.04


Chicago Style

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova. "Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease." Systematic Reviews in Pharmacy 11 (2020), 16-20. doi:10.31838/srp.2020.6.04


MLA (The Modern Language Association) Style

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova. "Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease." Systematic Reviews in Pharmacy 11.6 (2020), 16-20. Print. doi:10.31838/srp.2020.6.04


APA (American Psychological Association) Style

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova (2020) Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease. Systematic Reviews in Pharmacy, 11 (6), 16-20. doi:10.31838/srp.2020.6.04

ARTICLE TOOLS
ARTICLE TOOLS
Submit Article
Login
Register
Scan Code
Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3