Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus)
Abstract
Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan.
Research on the potential of anticholesterol degenerative drugs extract of purple C. roseus leaf tea water (Catharanthus roseus (L.) G. Don) in white male Wistar rats (Rattus novergicus) has been carried out. The purpose of this study was to determine the effect of giving extracts of water or steeping water of the C. roseus leaf in white male rats as a scientific study for the utilization of white or purple C. roseus leaves to be obtained degenerative especially to overcome excess cholesterol in humans. The method was carried out in stages starting with mouse rearing. White rat were previously induced with high fat from pigs for 40 days. The sample with two-color C. roseus leaf sampling, namely white and purple C. roseus. Drying and extraction with steeping simplicia in the form of tea, then treated to rat with atlibitum or drinking with a bottle sized for 10 days then blood analyzed with an enzymatic spectrometer. The treatments were divided into negative control, positive control and treatment with white C. roseus leaf tea 2 packs (4 g) and 1 pack (2 g) and purple white C. roseus leaf tea 2 packs (4 g) and 1 pack (2 g leaves tea powder), each brewed in 200 mL of hot water. The results showed that the water extract of the C. roseus leaves had an anti-cholesterol effect The best water extract of C. roseus leaf water was found in the treatment of one bag of purple flower C. roseus leaf water extract (2 g of powder) in 200 mL of hot water that is equal to 42.67 mg/dL. The average reduction in total cholesterol levels in the blood of white male rats treated by one tea bag (2 g) of purple C. roseus powder was 3.33 mg/dL. The extracted water of steeping C. roseus leaves with purple flowering is more effective in reducing total blood cholesterol levels compared to white flowering of C. roseus. The purple-flowered C. roseus has the potential to be used as an anti-cholesterol drug in degenerative diseases.
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| Pubmed Style Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan. Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus). SRP. 2020; 11(1): 618-625. doi:10.5530/srp.2020.1.78 Web Style Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan. Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus). http://www.sysrevpharm.org/?mno=86332 [Access: March 29, 2021]. doi:10.5530/srp.2020.1.78 AMA (American Medical Association) Style Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan. Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus). SRP. 2020; 11(1): 618-625. doi:10.5530/srp.2020.1.78 Vancouver/ICMJE Style Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan. Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus). SRP. (2020), [cited March 29, 2021]; 11(1): 618-625. doi:10.5530/srp.2020.1.78 Harvard Style Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan (2020) Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus). SRP, 11 (1), 618-625. doi:10.5530/srp.2020.1.78 Turabian Style Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan. 2020. Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus). Systematic Reviews in Pharmacy, 11 (1), 618-625. doi:10.5530/srp.2020.1.78 Chicago Style Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan. "Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus)." Systematic Reviews in Pharmacy 11 (2020), 618-625. doi:10.5530/srp.2020.1.78 MLA (The Modern Language Association) Style Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan. "Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus)." Systematic Reviews in Pharmacy 11.1 (2020), 618-625. Print. doi:10.5530/srp.2020.1.78 APA (American Psychological Association) Style Dingse Pandiangan, Paulina V. Y. Yamleam, Hendra Pratama Maliangkay, Endang Pudjihastuti, Michael Tumbol, Nelson Nainggolan (2020) Potential of Anticholesterol Degenerative Drugs of Leaf Extract (Catharanthus roseus (L.) G. Don) On Wistar Rat (Rattus norvegicus). Systematic Reviews in Pharmacy, 11 (1), 618-625. doi:10.5530/srp.2020.1.78 |
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