Abstract

Shweta Kumari64597*, Khushboo Raj64598, Saurabh Kumar Gupta64599 and Sudhanshu Mishra64600

This review currently focused on WNT, originates from wg, which means wingless and Ing denotes genes, having complicated network of ten homologous Frizzeled receptors (FzD), RYK (Receptor Like Tyrosine Kinase), Retinoic acid-related Orphan Receptors (RoR), Protein Tyrosine Kinase 7 (PTK7), Muscle Specific tyrosine Kinase (MuSK), co-receptors, Lipoprotein Receptor-related Protein (LRP5/6) and 19 cysteine rich glycolipoproteinswnt ligands. It is highly recommended pathways for the process of angiogenesis, embroyonic development by maintaining proliferation and differentiation. Most of the research is going in to know about cancer therapy or treatment by WNT pathways down regulation via canonical β-catenin dependent/ T-Cell Factor (TCF) pathway and non-ca-nonical β-catenin pathway. It is much needed way for developing the targeted therapies opposite to cancers, which involves phosphoryalation by Glycogen Synthase Kinase-3 (GSK-3) protein complex. In addition, there are some natural compounds which shows WNT pathway inhibitors. According to recent studies, Triple Negative Breast Cancer (TNBC) depends on WNT-pathway but no drugs are currently under clinical trials, it requires high cost in discovery and is a time consuming process. It clearly shows emergency for such type of drugs in cancer therapy.