Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited
Abstract
Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar
Depression is among the common psychiatric disorders, therefore the common pathways and pathogenesis associated with depression is required to be studied. In few years, role of 5-hydroxytryptamine-1A/B (5-HT1A/B) receptors in depressive disorders have been revealed. Both preclinical and clinical studies reported that the potential agonist and antagonist at 5-HT1A/B receptors have significant modulatory effects in depression. However, the collective details regarding the involvement of 5-HT1A/B receptors and the molecular pathways associated in depression is lacking. Thus, the present review evidence the link between 5-HT1A/B receptors in the brain and depression, the possible pathways involved and their alterations in depression. Further, it reviews the preclinical evidences of 5-HT1A/B receptor modulators as antidepressant agents and their effectiveness. The current review also details the clinical relevance of 5-HT1A/B receptors etiopathogenesis of major depression in humans.
| How to Cite this Article |
| Pubmed Style Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. SRP. 2013; 4(1): 7-13. doi:10.4103/0975-8453.135831 Web Style Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. http://www.sysrevpharm.org/?mno=302644588 [Access: March 28, 2021]. doi:10.4103/0975-8453.135831 AMA (American Medical Association) Style Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. SRP. 2013; 4(1): 7-13. doi:10.4103/0975-8453.135831 Vancouver/ICMJE Style Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. SRP. (2013), [cited March 28, 2021]; 4(1): 7-13. doi:10.4103/0975-8453.135831 Harvard Style Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar (2013) Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. SRP, 4 (1), 7-13. doi:10.4103/0975-8453.135831 Turabian Style Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. 2013. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. Systematic Reviews in Pharmacy, 4 (1), 7-13. doi:10.4103/0975-8453.135831 Chicago Style Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. "Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited." Systematic Reviews in Pharmacy 4 (2013), 7-13. doi:10.4103/0975-8453.135831 MLA (The Modern Language Association) Style Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. "Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited." Systematic Reviews in Pharmacy 4.1 (2013), 7-13. Print. doi:10.4103/0975-8453.135831 APA (American Psychological Association) Style Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar (2013) Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. Systematic Reviews in Pharmacy, 4 (1), 7-13. doi:10.4103/0975-8453.135831 |
Abstract
PDF
How to cite this article
Related Records