Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility
Abstract
Tiwari R, Tiwari G, Rai AK
Self-emulsifying drug delivery systems (SEDDSs) have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SEDDSs are mixtures of oils, surfactants, and cosurfactants, which are emulsified in aqueous media under conditions of gentle stirring and digestive motility that are encountered in the gastrointestinal (GI) tract. We found that SEDDSs could efficiently improve oral absorption of the sparingly soluble drugs by rapid self-emulsification and, subsequently, dispersion in the absorption sites. SEDDSs possess unparalleled potential in improving oral bioavailability of poorly water soluble drugs. Following their oral administration, these systems rapidly disperse in GI fluids, yielding micro-or nanoemulsions containing the solubilized drug. Owing to its miniscule globule size, the micro/nanoemulsifed drug can easily be absorbed through lymphatic pathways, bypassing the hepatic first-pass effect.<
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| Pubmed Style Tiwari R, Tiwari G, Rai AK. Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility. SRP. 2010; 1(2): 133-140. doi:10.4103/0975-8453.75055 Web Style Tiwari R, Tiwari G, Rai AK. Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility. http://www.sysrevpharm.org/?mno=302644617 [Access: March 28, 2021]. doi:10.4103/0975-8453.75055 AMA (American Medical Association) Style Tiwari R, Tiwari G, Rai AK. Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility. SRP. 2010; 1(2): 133-140. doi:10.4103/0975-8453.75055 Vancouver/ICMJE Style Tiwari R, Tiwari G, Rai AK. Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility. SRP. (2010), [cited March 28, 2021]; 1(2): 133-140. doi:10.4103/0975-8453.75055 Harvard Style Tiwari R, Tiwari G, Rai AK (2010) Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility. SRP, 1 (2), 133-140. doi:10.4103/0975-8453.75055 Turabian Style Tiwari R, Tiwari G, Rai AK. 2010. Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility. Systematic Reviews in Pharmacy, 1 (2), 133-140. doi:10.4103/0975-8453.75055 Chicago Style Tiwari R, Tiwari G, Rai AK. "Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility." Systematic Reviews in Pharmacy 1 (2010), 133-140. doi:10.4103/0975-8453.75055 MLA (The Modern Language Association) Style Tiwari R, Tiwari G, Rai AK. "Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility." Systematic Reviews in Pharmacy 1.2 (2010), 133-140. Print. doi:10.4103/0975-8453.75055 APA (American Psychological Association) Style Tiwari R, Tiwari G, Rai AK (2010) Self-Emulsifying Drug Delivery System: An Approach to Enhance Solubility. Systematic Reviews in Pharmacy, 1 (2), 133-140. doi:10.4103/0975-8453.75055 |
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