Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations
Abstract
Qabas Naji Rashid
A “sensitive, rapid and economical” spectrophotometric procedures for estimation of two drugs; Paracetamol (PAR) and Phenobarbital (PHE), by reaction with 4-chloro-7-nitrobenzofurazan (NBD-Cl) as reagent in an alkaline interemediate. These methods are summarized on the forming of “color products” among these drugs and the chromogenic reagent (NBD-Cl). Yellow colored product formed at (pH 11) and λmax. 466 nm for (PAR), and yellow colored product at (pH 11.5) and λmax. 472 nm for (PHE). Beer’s Law is obeyed in a concentrations range of (6-90 µg/ml), (12-80 µg/ml), with molar absorptivity (2.101×103 L/mol.cm), (3.507×103 L/mol.cm), and correlation coefficient 0.9992, 0.9988, respectively, the detection limits were (0.671 µg/ml, 2.273 µg/ml), respectively. Suggested procedure were prosperity implement to the estimation of “these drugs” in pure forms and in their pharmaceutical formulations as (Tablets).
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| Pubmed Style Qabas Naji Rashid. Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations . SRP. 2020; 11(1): 273-280. doi:10.5530/srp.2020.1.35 Web Style Qabas Naji Rashid. Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations . http://www.sysrevpharm.org/?mno=83791 [Access: March 29, 2021]. doi:10.5530/srp.2020.1.35 AMA (American Medical Association) Style Qabas Naji Rashid. Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations . SRP. 2020; 11(1): 273-280. doi:10.5530/srp.2020.1.35 Vancouver/ICMJE Style Qabas Naji Rashid. Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations . SRP. (2020), [cited March 29, 2021]; 11(1): 273-280. doi:10.5530/srp.2020.1.35 Harvard Style Qabas Naji Rashid (2020) Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations . SRP, 11 (1), 273-280. doi:10.5530/srp.2020.1.35 Turabian Style Qabas Naji Rashid. 2020. Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations . Systematic Reviews in Pharmacy, 11 (1), 273-280. doi:10.5530/srp.2020.1.35 Chicago Style Qabas Naji Rashid. "Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations ." Systematic Reviews in Pharmacy 11 (2020), 273-280. doi:10.5530/srp.2020.1.35 MLA (The Modern Language Association) Style Qabas Naji Rashid. "Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations ." Systematic Reviews in Pharmacy 11.1 (2020), 273-280. Print. doi:10.5530/srp.2020.1.35 APA (American Psychological Association) Style Qabas Naji Rashid (2020) Spectrophotometric Determination of Paracetamol and Phenobarbital in Raw Forms and in their Pharmaceutical Preparations . Systematic Reviews in Pharmacy, 11 (1), 273-280. doi:10.5530/srp.2020.1.35 |
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