Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound)
Abstract
Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al_Ali
A number of organo-selenium compounds have been planned and synthesized for pharmacological properties. A novel selena-diazole derivative compound[ 4', 4"- (4, 5, 6, 7- Tetrahydro- [1, 2, 3-] Selenadiazolo [4, 5e] Pyridine-4, 6-Diyl) Bis (Benzene-1, 3-Diol)] (SeD) was previously synthesized, identified.The main objective of the current study is the study of some of its pharmacological effects; include hematological profile, T and B lymphocytes count, effects on prothrombin time; also, SeD activity on thyroid hormone. Two groups of Wister female Rats, Control group (NS) and the second Test (SeD) group received a daily dose of 50 mg/Kg BW for one month. Complete Blood cell count; Deferential Lymphocytes count; Serum Thyroid hormones were evaluated; also, vitro Prothrombin Time (PT) international normalized ratio (INR) and activated partial thromboplastin time (a PTT) were estimated. The results indicate that a significantly increase in WBC and Lymphocytes%. While Granulocytes and blood platelets count were significantly decreased. a PTT and INR values were important differences with the heparin group (H). Total Lymphocytes, T cells and B cells of (SeD) greatly enhanced than control. TSH increased significantly, while T3 and T4 serum concentrations were significantly decline than control. It can be concluded that SeD can increased WBC and lymphocytes cells. SeD at low concentrations decreased were showed significant decline a PTT and PT-INR than Heparin treated group. Also, SeD has stimulating effects on TSH and inhibited T4 and T3 thyroid hormones.
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| Pubmed Style Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al Ali. Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound). SRP. 2020; 11(11): 975-980. doi:10.31838/srp.2020.11.140 Web Style Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al Ali. Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound). http://www.sysrevpharm.org/?mno=18842 [Access: March 29, 2021]. doi:10.31838/srp.2020.11.140 AMA (American Medical Association) Style Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al Ali. Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound). SRP. 2020; 11(11): 975-980. doi:10.31838/srp.2020.11.140 Vancouver/ICMJE Style Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al Ali. Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound). SRP. (2020), [cited March 29, 2021]; 11(11): 975-980. doi:10.31838/srp.2020.11.140 Harvard Style Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al Ali (2020) Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound). SRP, 11 (11), 975-980. doi:10.31838/srp.2020.11.140 Turabian Style Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al Ali. 2020. Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound). Systematic Reviews in Pharmacy, 11 (11), 975-980. doi:10.31838/srp.2020.11.140 Chicago Style Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al Ali. "Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound)." Systematic Reviews in Pharmacy 11 (2020), 975-980. doi:10.31838/srp.2020.11.140 MLA (The Modern Language Association) Style Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al Ali. "Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound)." Systematic Reviews in Pharmacy 11.11 (2020), 975-980. Print. doi:10.31838/srp.2020.11.140 APA (American Psychological Association) Style Nadheerah F. Neamah, Shaker.A.N.Al-Jadaan, Asmaa M. Al Ali (2020) Study of some of Novel Selena-Diazole Derivative activities on Hematological Parameters, Differentiate lymphocytes cells in addition to thyroid hormones levels in Female Rats (One of the series of studies on the impact of the new compound). Systematic Reviews in Pharmacy, 11 (11), 975-980. doi:10.31838/srp.2020.11.140 |
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