Abstract

Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail

In chronic kidney disease (CKD), kidneys develop injured over time and don’t work properly as in the kidneys for healthy people. At what time the kidneys cannot blood clean, further liquids stay and wastes in the body and which leads to many problems in health, such as high blood pressure (BP) and cardiovascular disease (CVD). In current study, we attempt to examine the association of asprosin (APN) and dickkopf-3 (DKK-3) with kidney injury molecule-1 (KIM-1), N-terminal pro-brain natriuretic peptide (NTpro-BNP), growth differentiation factor 15 (GDF-15) and copeptin (CPP) among male Iraqi with CKD.
Methods: serum APN, DKK-3, KIM-1, NTpro-BNP, GDF-15 and CPP were determined by ELISA technique in 40 healthy controls (HCs) and 44 male patients with CKD, from the Al-Fallujah teaching hospital were recorded in this paper, serum concentrations of urea, creatinine and estimated glomerular filtration rate (eGFR) were measured by colorimetric methods
Results: serum APN and DKK-3 were importantly greater in CKD males than in HCs (P<0.0001) and they positively associated with KIM-1, NTpro-BNP, GDF-15 and CPP (P<0.01), also serum concentration of ANP was positively associated DKK-3 (P<01). Studied variables presented the following descending order of area under the receiver operating characteristic (AUROC) curve urea, creatinine and e GFR (1for all, P<0.0001), KIM-1(0.9896), APN (0.939), CPP (0.8966), DKK-3 (0.893), NTpro-BNP (0.8558) and GDF-15 (0.8375) respectively (P<0.0001for all).
Conclusion: serum levels APN, DKK3 KIM-1, NTpro-BNP, GDF-15 and CPP may be a biomarker of renal damage in CKD development in Iraqi males.

 

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Pubmed Style Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail. Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.. SRP. 2020; 11(5): 10-17. doi:10.31838/srp.2020.5.02 Web Style Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail. Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.. http://www.sysrevpharm.org/?mno=106519 [Access: March 29, 2021]. doi:10.31838/srp.2020.5.02 AMA (American Medical Association) Style Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail. Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.. SRP. 2020; 11(5): 10-17. doi:10.31838/srp.2020.5.02 Vancouver/ICMJE Style Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail. Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.. SRP. (2020), [cited March 29, 2021]; 11(5): 10-17. doi:10.31838/srp.2020.5.02 Harvard Style Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail (2020) Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.. SRP, 11 (5), 10-17. doi:10.31838/srp.2020.5.02 Turabian Style Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail. 2020. Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.. Systematic Reviews in Pharmacy, 11 (5), 10-17. doi:10.31838/srp.2020.5.02 Chicago Style Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail. "Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.." Systematic Reviews in Pharmacy 11 (2020), 10-17. doi:10.31838/srp.2020.5.02 MLA (The Modern Language Association) Style Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail. "Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.." Systematic Reviews in Pharmacy 11.5 (2020), 10-17. Print. doi:10.31838/srp.2020.5.02 APA (American Psychological Association) Style Shakir F. T. Alaaraji, Muthanna M. Awad, Mohammed A. Ismail (2020) Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.. Systematic Reviews in Pharmacy, 11 (5), 10-17. doi:10.31838/srp.2020.5.02