Abstract

Noor T. Tahir, Israa Q. Falih, Faten Khudhair AL_Husaini, Sali Abed Zeghair

Diabetes Mellitus (DM) is metabolic disease having great effect on our health. the associated complications of diabetes that included cardiovascular disease, retinopathy, become raised at un regulating glucose. The development of Diabetic retinopathy (DR) has deeply attaching with oxidative damage, inflammation and various pro-angiogenic cytokines.
Aim of study: The presented study was designed to assess the effect of serum chemerin levels in type 2 diabetes patients with diabetic retinopathy and without diabetic retinopathy, and its relation to certain biochemical analysis.
Patients and methods: A total of 90 subjects participated in this research. They were divided into three groups, with 30 persons in the type 2 diabetic retinopathy group, 30 persons in the type 2 without diabetic retinopathy group, and another 30 healthy persons (aged between 33-55 years) in a control group, for comparison. Studies were carried out at the National Diabetic Center at Al-Mustansirya University. A significant increase in waist circumference, body mass index, fasting blood sugar, glycosylated haemoglobin, C-peptide, homeostasis model assessment-2 insulin resistance, B-cell % and Sensitivity % levels was found in both the type 2 diabetic retinopathy and type 2 without diabetic retinopathy groups, as compared with the control group.
Results: Serum chemerin and HS-CRP levels have a highly significant increase different (P<0.001) among type 2 diabetics with diabetic retinopathy and type 2 diabetics without diabetic retinopathy when compared with the control group. It was found that chemerin level is significantly higher in type 2 diabetic patients with diabetic retinopathy, as compared to type 2 diabetic patients without diabetic retinopathy and the control group.
Conclusion:The significant difference in chemerin (fasting blood sugar, insulin resistance, total cholesterol, triglyceride, low density lipoprotein and high sensitive c-reactive protein) between the type 2 diabetic group with diabetic retinopathy and type 2 diabetic group without diabetic retinopathy leads to the conclusion that the high levels of chemerin paved the pathogenesis diabetic retinopathy by enhancing inflammation, insulin resistance, oxidative stress and angiogenesis factor.