Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis
Abstract
Shaimaa H. Ali, Rawaa S. A. AL-Azawi, Hamzah H. Kzar.
Background: The chronic inflammatory skin disease with a strong genetic predisposition and autoimmune pathogenic traits is called Psoriasis.
Aim: Study the IL6 (C174G) promoter polymorphisms and correlation with growth factor and TNFA activity in patients with psoriasis in Iraqi population. Subjects and Methods: This study is included 40 subjects (24 males and 16 females) with psoriasis at range of age (11-40) years with mean±SD was (29±11) years and divided into two groups. The control group included 20 subjects matched with age and gender of psoriasis group. GH and TNFA levels were estimated by use of ELISA technique. DNA was extracted from whole blood of both groups and PCR-RFLP was used to perform the genotyping analysis.
Results: The results suggesting highly significant differences in GH and TNFA levels between psoriasis and control group (p-value< 0.05). The results showing statistical differences (odd ratio) in CC, CG, and GG between psoriasis and control groups.
Conclusion: C174G polymorphism in promoter of IL6 gene with increasing in GH and TNFA levels consider a risk factor for incidence of psoriasis in different ages and genders.
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| Pubmed Style Ali SH, AL-Azawi RSA, Kzar HH. Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis. SRP. 2020; 11(9): 272-276. doi:10.31838/srp.2020.9.44 Web Style Ali SH, AL-Azawi RSA, Kzar HH. Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis. http://www.sysrevpharm.org/?mno=7134 [Access: March 29, 2021]. doi:10.31838/srp.2020.9.44 AMA (American Medical Association) Style Ali SH, AL-Azawi RSA, Kzar HH. Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis. SRP. 2020; 11(9): 272-276. doi:10.31838/srp.2020.9.44 Vancouver/ICMJE Style Ali SH, AL-Azawi RSA, Kzar HH. Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis. SRP. (2020), [cited March 29, 2021]; 11(9): 272-276. doi:10.31838/srp.2020.9.44 Harvard Style Ali, S. H., AL-Azawi, . R. S. A. & Kzar, . H. H. (2020) Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis. SRP, 11 (9), 272-276. doi:10.31838/srp.2020.9.44 Turabian Style Ali, Shaimaa H., Rawaa S. A. AL-Azawi, and Hamzah H. Kzar. 2020. Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis. Systematic Reviews in Pharmacy, 11 (9), 272-276. doi:10.31838/srp.2020.9.44 Chicago Style Ali, Shaimaa H., Rawaa S. A. AL-Azawi, and Hamzah H. Kzar. "Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis." Systematic Reviews in Pharmacy 11 (2020), 272-276. doi:10.31838/srp.2020.9.44 MLA (The Modern Language Association) Style Ali, Shaimaa H., Rawaa S. A. AL-Azawi, and Hamzah H. Kzar. "Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis." Systematic Reviews in Pharmacy 11.9 (2020), 272-276. Print. doi:10.31838/srp.2020.9.44 APA (American Psychological Association) Style Ali, S. H., AL-Azawi, . R. S. A. & Kzar, . H. H. (2020) Study the IL6 (C174G) Promoter SNP and Correlation with Physiological Growth Hormone and TNFA levels in Iraqi Subjects with Psoriasis. Systematic Reviews in Pharmacy, 11 (9), 272-276. doi:10.31838/srp.2020.9.44 |
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