Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme
Abstract
Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali.
Objective To synthesize and initial pharmacological evaluation of new derivatives of nabumetone by incorporating of triazole heterocyclic ring systems into the nabumetone moiety to optimize the activity against COX enzymes. Examination of their in vivo results by using egg white to induce acute inflammation.
Methods A group of triazole carrying nabumetone moiety have been designed, prepared, and assessed as a potential COX- inhibitors. These new derivatives were evaluated for their in vivo anti-inflammatory activity.
Results most of the tested compounds have good results in acute anti-inflammatory in vivo tests better than nabumetone.
Conclusion The synthesis of the designed derivatives (3a-e) has been successfully occurred , the anti-inflammatory evaluation of the final products shows that the addition of triazole pharmacophore into nabumetone enhanced its anti- inflammatory activity, the Preliminary study of anti-inflammatory action indicates that compound (3a-e especially 3c and 3d) have significantly more anti-inflammatory outcome than nabumetone( except 3b ).
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| Pubmed Style Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali. Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme. SRP. 2021; 12(1): 190-195. doi:10.31838/srp.2021.1.30 Web Style Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali. Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme. http://www.sysrevpharm.org/?mno=6920 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.30 AMA (American Medical Association) Style Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali. Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme. SRP. 2021; 12(1): 190-195. doi:10.31838/srp.2021.1.30 Vancouver/ICMJE Style Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali. Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme. SRP. (2021), [cited March 29, 2021]; 12(1): 190-195. doi:10.31838/srp.2021.1.30 Harvard Style Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali (2021) Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme. SRP, 12 (1), 190-195. doi:10.31838/srp.2021.1.30 Turabian Style Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali. 2021. Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme. Systematic Reviews in Pharmacy, 12 (1), 190-195. doi:10.31838/srp.2021.1.30 Chicago Style Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali. "Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme." Systematic Reviews in Pharmacy 12 (2021), 190-195. doi:10.31838/srp.2021.1.30 MLA (The Modern Language Association) Style Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali. "Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme." Systematic Reviews in Pharmacy 12.1 (2021), 190-195. Print. doi:10.31838/srp.2021.1.30 APA (American Psychological Association) Style Hussien A. Karim, Ayad M.R. Raauf, and Karima F. Ali (2021) Synthesis and preliminary pharmacological evaluation of some new triazole derivatives bearing nabumetone moiety targeting cyclooxygenase enzyme. Systematic Reviews in Pharmacy, 12 (1), 190-195. doi:10.31838/srp.2021.1.30 |
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