Abstract

Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi

Background: A novel myokine, named Irisin, was identified in human that secreted by skeletal muscle after exercise. Irisin increases energy expenditure by turning white adipose tissue into brown adipose tissue. Irisin is considered as a potential biomarker for obesity and metabolic syndrome.
Objectives: To investigate the maternal/fetal concentrations of the myokine irisin in intrauterine growth restricted (IUGR) fetuses versus large for gestational age (LGA) and appropriate for gestational age (AGA) and the correlation of irisin with fetal growth pattern birth weight.
Methods: A case – control study conducted at Al-Yarmouk teaching hospital from the 1st of January,2017 to the 1st of January 2018. Ninety six pregnant women between (20_40 )years old all with singleton pregnancies, gestational age from 37+0 – 40+6 weeks were involved in the study and were divided into three groups: (Group 1) 32 cases with their fetal weight for gestational age between 10th_90th percentile AGA the case group, the control group, (Group 2) 32 cases with their fetal weight for gestational age<10th percentile IUGR and (Group 3) 32 cases with their fetal weight for gestational age>90th percentile LGA, the case group. In all groups, we measured maternal blood irisin &umbilical cord blood irisin, by using ELIZA kits.
Results:
The study involved 32 cases for each control AGA, IUGR and LGA groups.GA was significantly lower in IUGR compared to both LGA and control, ponderal index (PI) was lower in IUGR compared to both LGA (p-value <0.001), and control (p-value <0.001). Fetal irisin was significantly lower in IUGR (0.08 ± 0.05) μg/ml compared to control (2.17 ± 0.79) μg/ml and LGA (2.25 ± 0.80) μg/ml, no significant difference between LGA and control. Maternal irisin was significantly lower in IUGR (0.29 ± 0.11) μg/ml compared to control (2.35 ± 0.76) μg/ml and LGA (2.44 ± 0.78) μg/ml. In LGA and IUGR there was direct significant correlation between fetal and maternal irisin, Maternal irisin had excellent ability to predict IUGR with cut point≤0.43, sensitivity99% and specificity 99%.
Conclusions: maternal blood irisin level directly correlated with fetal blood irisin level. Both maternal &fetal Irisin blood level directly correlated with fetal growth pattern &birth weight. Maternal irisin level best to use as an indirect biomarker for IUGR.

 

How to Cite this Article

Pubmed Style Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi. The Correlation of Maternal and Fetal Blood Irisin with Fetal Growth Pattern and Birth Weight. SRP. 2021; 12(1): 359-366. doi:10.31838/srp.2021.1.56 Web Style Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi. The Correlation of Maternal and Fetal Blood Irisin with Fetal Growth Pattern and Birth Weight. http://www.sysrevpharm.org/?mno=36121 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.56 AMA (American Medical Association) Style Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi. The Correlation of Maternal and Fetal Blood Irisin with Fetal Growth Pattern and Birth Weight. SRP. 2021; 12(1): 359-366. doi:10.31838/srp.2021.1.56 Vancouver/ICMJE Style Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi. The Correlation of Maternal and Fetal Blood Irisin with Fetal Growth Pattern and Birth Weight. SRP. (2021), [cited March 29, 2021]; 12(1): 359-366. doi:10.31838/srp.2021.1.56 Harvard Style Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi (2021) The Correlation of Maternal and Fetal Blood Irisin with Fetal Growth Pattern and Birth Weight. SRP, 12 (1), 359-366. doi:10.31838/srp.2021.1.56 Turabian Style Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi. 2021. The Correlation of Maternal and Fetal Blood Irisin with Fetal Growth Pattern and Birth Weight. Systematic Reviews in Pharmacy, 12 (1), 359-366. doi:10.31838/srp.2021.1.56 Chicago Style Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi. "The Correlation of Maternal and Fetal Blood Irisin with Fetal Growth Pattern and Birth Weight." Systematic Reviews in Pharmacy 12 (2021), 359-366. doi:10.31838/srp.2021.1.56 MLA (The Modern Language Association) Style Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi. "The Correlation of Maternal and Fetal Blood Irisin with Fetal Growth Pattern and Birth Weight." Systematic Reviews in Pharmacy 12.1 (2021), 359-366. Print. doi:10.31838/srp.2021.1.56 APA (American Psychological Association) Style Esraa Hameed Humadi Al-Maini, Maysoon Shallal Mizher, Farah Fadhil Shafi (2021) The Correlation of Maternal and Fetal Blood Irisin with Fetal Growth Pattern and Birth Weight. Systematic Reviews in Pharmacy, 12 (1), 359-366. doi:10.31838/srp.2021.1.56