The Effect of Cordyline terminalis?s Leaf Extract on Lipid Profile, Obesity and Liver Function in Obese Induced Rats

Abstract

Ni Wayan Bogoriani, Ni Made Suaniti, Anak Agung Bawa Putra, Kadek Dwi Pradnya Lestari, Wayan Eka Heltyani

A high diet in saturated fat and lack of physical activity can increase blood plasma fat content and can cause obesity, which is a risk factor for coronary heart disease, type 2 diabetes mellitus, hyperlipidemic, atherosclerosis, liver function dan hypertension. This study aimed to observe effect of andong leave extract (Cordyline terminalis) on the profile of lipid, obesity and function of liver onrats. The study was conducted using 24 wistar rats, which was divided into 4 groups: six rats were as control with a standard diet (group I) and 18 rats were obese induced by high-fat diet for 3 groups: Group II obesity with high-fat diet (HFD), Group III and IV (obesity plus extract 100 mg / kgbw and 200 mg / kgbw). Rats received andong leaf extract orally after induction of obesity. After 30 days of research the rat’s blood was drawn for testing of lipid profile, obesity, and liver function. The results showed that a decrease in body weight, Lee Obesity Index (LOI), abdominal circumference (AC),visceral fat weights, organs weight, daily diet intake, and serum total cholesterol (TC), LDL cholesterol, triglycerides (TG), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and an increase in serum HDL cholesterol, daily fecal weight, total cholesterol and fat in feces by significant (p < 0.05) in the treatment extract of andong leave than HFD group. According to the research results it can be concluded that the andong leaf extract are proven to have hypolipidemic effects, antiobesity and improve liver function in rats