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THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT

Abstract

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas.

Atopic dermatitis is a chronic, residive inflammatory skin condition characterized by severe pruritus. Pathophysiology of AD is a multifactorial, skin barrier disorder, and involves altered immune response, it can be seen in rural population which exposed from many worm infections with a low prevalence of allergic disease and has been shown in animal models by stimulating the formation of TGF β and interleukin-10 (IL-10) inhibiting IL-4, IL-5, IL13 by stimulating Treg. To determine the effect of Lumbricus Rubellus extract, it can increase interleukin 10 and reduce IL-4, immunoglobulin E and eosinophils and it can provide clinical improvement in Atopic Dermatitis patients. This research used "Pretest-Posttest Design" method of mild atopic dermatitis patients who were not infected with worms. Lumbricus Rubellus extract was given for 2 weeks and checked for eosinophils and ELISA to determine IL-10 and IgE levels on day 0, 8 and 15. Statistical test used non-parametric tests, such as Mann-Whitney test (U-Test) and Wilcoxon test to determine whether there was a difference between two different treatments or not. There was a difference (p <0.05) between Lumbricus Rubellus extract group and the group without Lumbricus Rubellus extract on day 8, at day 15 there was no significant difference (p> 0.05) there was still an increase in IL levels. -10 and decreased levels of IgE and eosinophil. The side effects that appeared at research were intestinal disorders, such as nausea and bowel disorders of a research subject. Lumbricus Rubellus extract has an immune response effect towards people with atopic dermatitis.

How to Cite this Article
Pubmed Style

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas. THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT . SRP. 2020; 11(10): 1039-1065. doi:10.31838/srp.2020.10.153

Web Style

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas. THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT . http://www.sysrevpharm.org/?mno=51237 [Access: March 30, 2021]. doi:10.31838/srp.2020.10.153

AMA (American Medical Association) Style

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas. THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT . SRP. 2020; 11(10): 1039-1065. doi:10.31838/srp.2020.10.153


Vancouver/ICMJE Style

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas. THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT . SRP. (2020), [cited March 30, 2021]; 11(10): 1039-1065. doi:10.31838/srp.2020.10.153


Harvard Style

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas (2020) THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT . SRP, 11 (10), 1039-1065. doi:10.31838/srp.2020.10.153


Turabian Style

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas. 2020. THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT . Systematic Reviews in Pharmacy, 11 (10), 1039-1065. doi:10.31838/srp.2020.10.153


Chicago Style

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas. "THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT ." Systematic Reviews in Pharmacy 11 (2020), 1039-1065. doi:10.31838/srp.2020.10.153


MLA (The Modern Language Association) Style

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas. "THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT ." Systematic Reviews in Pharmacy 11.10 (2020), 1039-1065. Print. doi:10.31838/srp.2020.10.153


APA (American Psychological Association) Style

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas (2020) THE EFFECT OF LUMBRICUS RUBELLUS EXTRACTS ON IL-4, IL-10, IgE, AND EOSINOFIL LEVELS IN ATOPIC DERMATITIS PATIENT . Systematic Reviews in Pharmacy, 11 (10), 1039-1065. doi:10.31838/srp.2020.10.153

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