The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.)
Abstract
Imanuel Berly Delvis Kapelle, Wasmen Manalu, Meillisa Carlen Mainassy, Nini Munirah Renur, Shielda Natalia Joris.
The asymmetric curcumin analogue synthesized from cullilawan oil has a dioxolane active ring, so it can function as hepatoprotection. The chemical compound structure of the synthetic product influences the pharmacological properties. This study aimed to determine the hepatoprotection effect of the asymmetric curcumin analogue synthetic product in male rat (Rattus norvegicus L.) induced by carbon tetrachloride (CCl4). Turmeric extract and Hepa-Q commercial drug products are used as a comparison. The method used is the in vivo method using male rats by looking at Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvate Transaminase SPGT) values and histopathological analysis using the H&E method. The results showed that the asymmetric analogue of curcumin synthesized using the microwave method gave better results than conventional methods. The effective dose of hepatoprotection in male rats is 52 mg/200 g of bodyweight.
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| Pubmed Style Kapelle IBD, Manalu W, Mainassy MC, Renur NM, Joris SN. The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.). SRP. 2020; 11(10): 766-771. doi:10.31838/srp.2020.10.114 Web Style Kapelle IBD, Manalu W, Mainassy MC, Renur NM, Joris SN. The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.). http://www.sysrevpharm.org/?mno=10416 [Access: March 31, 2021]. doi:10.31838/srp.2020.10.114 AMA (American Medical Association) Style Kapelle IBD, Manalu W, Mainassy MC, Renur NM, Joris SN. The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.). SRP. 2020; 11(10): 766-771. doi:10.31838/srp.2020.10.114 Vancouver/ICMJE Style Kapelle IBD, Manalu W, Mainassy MC, Renur NM, Joris SN. The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.). SRP. (2020), [cited March 31, 2021]; 11(10): 766-771. doi:10.31838/srp.2020.10.114 Harvard Style Kapelle, I. B. D., Manalu, . W., Mainassy, . M. C., Renur, . N. M. & Joris, . S. N. (2020) The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.). SRP, 11 (10), 766-771. doi:10.31838/srp.2020.10.114 Turabian Style Kapelle, Imanuel Berly Delvis, Wasmen Manalu, Meillisa Carlen Mainassy, Nini Munirah Renur, and Shielda Natalia Joris. 2020. The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.). Systematic Reviews in Pharmacy, 11 (10), 766-771. doi:10.31838/srp.2020.10.114 Chicago Style Kapelle, Imanuel Berly Delvis, Wasmen Manalu, Meillisa Carlen Mainassy, Nini Munirah Renur, and Shielda Natalia Joris. "The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.)." Systematic Reviews in Pharmacy 11 (2020), 766-771. doi:10.31838/srp.2020.10.114 MLA (The Modern Language Association) Style Kapelle, Imanuel Berly Delvis, Wasmen Manalu, Meillisa Carlen Mainassy, Nini Munirah Renur, and Shielda Natalia Joris. "The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.)." Systematic Reviews in Pharmacy 11.10 (2020), 766-771. Print. doi:10.31838/srp.2020.10.114 APA (American Psychological Association) Style Kapelle, I. B. D., Manalu, . W., Mainassy, . M. C., Renur, . N. M. & Joris, . S. N. (2020) The Hepatoprotection Effect of the Asymmetric Curcumin Analogue Synthetic Product in Male Rat Abstract (Rattus norvegicus L.). Systematic Reviews in Pharmacy, 11 (10), 766-771. doi:10.31838/srp.2020.10.114 |
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