Abstract

Nawras Najah Mubark, Kareem Hamed Ghali, Jafar A. Al-maamori

Asthma is a chronic reversible airway disease, results from genetic – environmental interaction. Inflammatory processes may aggravate the severity of asthma and stimulate the airway remodeling. The aim of the current study is to evaluate the association between the negative inflammatory regulators; tumor necrosis factor α induced protein 8 like 2 (TIPE2) and Programmed cell death-1 (PD-1 with bronchial asthma in Iraqi population. blood samples are collected from 100 patients diagnosed with bronchial asthma (59 females and 41 males), their ages ranged between 2 to 61 years and 30 healthy individuals (14 females and 16 males) with the same age range. DNA extracted and then subjected to real time PCR for detection of gene expression. TIPE2 and PD-1 have low folding change of genes expression in asthmatic patients (0.01 and 0.10 respectively) compared to healthy control (1.00) which is reflect the significant differences (p<0.05). TIPE2 and PD-1 that have down expression (folding mean) in patients with familial asthma and the noted expression of these genes are clearly appeared in females (0.02 and 0.14 respectively). Also the lowest level of PD-1 gene expression was seen in unclassified group and then in moderate persist asthma (0.02, 0.11 respectively). While the lowest level of TIPE2 gene expression was seen in sever persist asthma, then moderate persist asthma and unclassified group (0.005, 0.006 and 0.008 respectively) .PD1 not affected by treatment but TIPE2 affected and increased. There are a significant negative correlation for each one of TIPE2, PD-1 with asthma infection.

How to Cite this Article

Pubmed Style Mubark NN, Ghali KH, Al-maamori JA. The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma. SRP. 2020; 11(1): 69-75. doi:10.5530/srp.2020.1.11 Web Style Mubark NN, Ghali KH, Al-maamori JA. The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma. http://www.sysrevpharm.org/?mno=302645238 [Access: March 28, 2021]. doi:10.5530/srp.2020.1.11 AMA (American Medical Association) Style Mubark NN, Ghali KH, Al-maamori JA. The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma. SRP. 2020; 11(1): 69-75. doi:10.5530/srp.2020.1.11 Vancouver/ICMJE Style Mubark NN, Ghali KH, Al-maamori JA. The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma. SRP. (2020), [cited March 28, 2021]; 11(1): 69-75. doi:10.5530/srp.2020.1.11 Harvard Style Mubark, N. N., Ghali, . K. H. & Al-maamori, . J. A. (2020) The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma. SRP, 11 (1), 69-75. doi:10.5530/srp.2020.1.11 Turabian Style Mubark, Nawras Najah, Kareem Hamed Ghali, and Jafar A. Al-maamori. 2020. The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma. Systematic Reviews in Pharmacy, 11 (1), 69-75. doi:10.5530/srp.2020.1.11 Chicago Style Mubark, Nawras Najah, Kareem Hamed Ghali, and Jafar A. Al-maamori. "The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma." Systematic Reviews in Pharmacy 11 (2020), 69-75. doi:10.5530/srp.2020.1.11 MLA (The Modern Language Association) Style Mubark, Nawras Najah, Kareem Hamed Ghali, and Jafar A. Al-maamori. "The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma." Systematic Reviews in Pharmacy 11.1 (2020), 69-75. Print. doi:10.5530/srp.2020.1.11 APA (American Psychological Association) Style Mubark, N. N., Ghali, . K. H. & Al-maamori, . J. A. (2020) The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma. Systematic Reviews in Pharmacy, 11 (1), 69-75. doi:10.5530/srp.2020.1.11