The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient?s diagnostic with Antiphospholipid Syndrome
Abstract
Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli
Background: Low level of protein Z associated with genetic background is being fundamental as it is interfering with PZ gene polymorphism and it can be combined with highly incidence of thrombosis. The purpose of this study is to analyse the prevalence and clinical significance for the PROZ (PZ) polymorphism in Iraqi patient’s diagnostic with antiphospholipid syndrome (APS), one from three main kinds of thrombophilia that is distinguished through the accumulation of antiphospholipid (aPL) antibodies (Abs).
Results: The target fragment 320 bp of PROZ gene (spanning PZ intron F region) was amplified in 65 samples including 32 women diagnostics with antiphospholipid syndrome and 33 controls. The G/A222 SNP which was previously known rs3024735 was detected in intronic sequences of the PROZ gene. G/A222 SNP was only localized in two groups of the investigated PROZ gene samples in comparison with their corresponding referring DNA sequences. The distribution of PROZ genotypes within the patients and healthy group of study, revealed no significant differences (P value = <0.81), in the mutant G/A and G/G normal genotypes. The incidence of the A allele was nearly similar between the control (0.24%) and APS group (0.26%) (P value = <0.84).
Conclusion: there is no association between the rs3024735 SNP on PZ intron F region amplicon and the risk of disease incidence in Iraqi patients previously diagnostic with APS and pregnancy morbidities
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| Pubmed Style Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli. The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient’s diagnostic with Antiphospholipid Syndrome. SRP. 2020; 11(12): 1312-1317. doi:10.31838/srp.2020.12.192 Web Style Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli. The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient’s diagnostic with Antiphospholipid Syndrome. http://www.sysrevpharm.org/?mno=13169 [Access: March 29, 2021]. doi:10.31838/srp.2020.12.192 AMA (American Medical Association) Style Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli. The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient’s diagnostic with Antiphospholipid Syndrome. SRP. 2020; 11(12): 1312-1317. doi:10.31838/srp.2020.12.192 Vancouver/ICMJE Style Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli. The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient’s diagnostic with Antiphospholipid Syndrome. SRP. (2020), [cited March 29, 2021]; 11(12): 1312-1317. doi:10.31838/srp.2020.12.192 Harvard Style Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli (2020) The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient’s diagnostic with Antiphospholipid Syndrome. SRP, 11 (12), 1312-1317. doi:10.31838/srp.2020.12.192 Turabian Style Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli. 2020. The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient’s diagnostic with Antiphospholipid Syndrome. Systematic Reviews in Pharmacy, 11 (12), 1312-1317. doi:10.31838/srp.2020.12.192 Chicago Style Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli. "The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient’s diagnostic with Antiphospholipid Syndrome." Systematic Reviews in Pharmacy 11 (2020), 1312-1317. doi:10.31838/srp.2020.12.192 MLA (The Modern Language Association) Style Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli. "The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient’s diagnostic with Antiphospholipid Syndrome." Systematic Reviews in Pharmacy 11.12 (2020), 1312-1317. Print. doi:10.31838/srp.2020.12.192 APA (American Psychological Association) Style Zeena Hadi Obaid Alwan, Rafal Ahmed AL- Gelawi, and Nadia M. AL- Hilli (2020) The relation of PROZ1 polymorphism and risk of early fetal loss in Iraqi patient’s diagnostic with Antiphospholipid Syndrome. Systematic Reviews in Pharmacy, 11 (12), 1312-1317. doi:10.31838/srp.2020.12.192 |
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