Abstract

Hala Hussain Hadi, Eman Saadi Saleh, Mohammed Hadi Al Osami, Khulood Azeez Anber

Ankylosing spondylitis (AS) is arthritis that affects the spine cause inflammatory stiffening of it. The disease affects both cartilaginous joints of the spine and the sacroiliac joints. Ossification of ligaments and spinal fusion with a typical stooped posture has been shown when disease was developed. Tobacco smoking consist of a complex mixture of various agents had many toxic effects so it has a negative influence on spinal activity, functional ability and mobility in AS. The pathogenesis of AS is imprecise and possible of several pro-inflammatory cytokine formation is leading to many pathogenic consequences. The liver responsible for releasing several types of acute phase proteins (APP) containing the fetuin- A (FA) as counter-regulatory mechanism. Vitamin D (VD) is very important for bone health, and has also been linked with immune function and protection against cancer. This study was designed to clarify the impact tobacco smoking on serum fetuin A, vitamin D and tumor necrosis factor alpha (TNF-α) levels in Iraqi male with ankylosing spondylitis. Cross- sectional study was done in Baghdad Teaching Hospital/ Medical City from April to August 2016. The number of both AS and volunteers are seventy-eight; their mean age were (36.53 ± 8.46) and (33.04 ± 9.74) years respectively. All of them were classified into four groups depending on healthy status and tobacco smoke. Blood sample was drawn from vein of each participant to determine the above serum biomarkers by ELISA. The result showed not significant variations in measuring hemoglobin (HGB) but significant increase of white blood cells (WBCs), platelets count and erythrocyte sedimentation rate (ESR){P values list > 0.05, < 0.05, < 0.05 and <0.01 respectively}. There is high significant decrease in serum VD and FA (P value= 0.00 and P value< 0.01) with increasing of TNF-α (P value <0.01) among four different groups. From the result be accomplish that fetuin A with vitamin D and TNF-α play essential role in prognosis and etiology of AS whether smoke cigarette or not. This study be the first done in Iraqi AS male to assess the effect of smoking on selected serum biomarkers especially fetuin A.

 

How to Cite this Article

Pubmed Style Hadi HH, Saleh ES, Osami MHA, Anber KA. The relationship between smoking and ankylosing spondylitis on some serum biomarkers. SRP. 2021; 12(1): 149-154. doi:10.31838/srp.2021.1.24 Web Style Hadi HH, Saleh ES, Osami MHA, Anber KA. The relationship between smoking and ankylosing spondylitis on some serum biomarkers. http://www.sysrevpharm.org/?mno=2729 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.24 AMA (American Medical Association) Style Hadi HH, Saleh ES, Osami MHA, Anber KA. The relationship between smoking and ankylosing spondylitis on some serum biomarkers. SRP. 2021; 12(1): 149-154. doi:10.31838/srp.2021.1.24 Vancouver/ICMJE Style Hadi HH, Saleh ES, Osami MHA, Anber KA. The relationship between smoking and ankylosing spondylitis on some serum biomarkers. SRP. (2021), [cited March 29, 2021]; 12(1): 149-154. doi:10.31838/srp.2021.1.24 Harvard Style Hadi, H. H., Saleh, . E. S., Osami, . M. H. A. & Anber, . K. A. (2021) The relationship between smoking and ankylosing spondylitis on some serum biomarkers. SRP, 12 (1), 149-154. doi:10.31838/srp.2021.1.24 Turabian Style Hadi, Hala Hussain, Eman Saadi Saleh, Mohammed Hadi Al Osami, and Khulood Azeez Anber. 2021. The relationship between smoking and ankylosing spondylitis on some serum biomarkers. Systematic Reviews in Pharmacy, 12 (1), 149-154. doi:10.31838/srp.2021.1.24 Chicago Style Hadi, Hala Hussain, Eman Saadi Saleh, Mohammed Hadi Al Osami, and Khulood Azeez Anber. "The relationship between smoking and ankylosing spondylitis on some serum biomarkers." Systematic Reviews in Pharmacy 12 (2021), 149-154. doi:10.31838/srp.2021.1.24 MLA (The Modern Language Association) Style Hadi, Hala Hussain, Eman Saadi Saleh, Mohammed Hadi Al Osami, and Khulood Azeez Anber. "The relationship between smoking and ankylosing spondylitis on some serum biomarkers." Systematic Reviews in Pharmacy 12.1 (2021), 149-154. Print. doi:10.31838/srp.2021.1.24 APA (American Psychological Association) Style Hadi, H. H., Saleh, . E. S., Osami, . M. H. A. & Anber, . K. A. (2021) The relationship between smoking and ankylosing spondylitis on some serum biomarkers. Systematic Reviews in Pharmacy, 12 (1), 149-154. doi:10.31838/srp.2021.1.24