The Relationship between Some Pro-inflammatory Markers and BODE Index in Patients with Chronic Obstructive Pulmonary Disease

Abstract

Yesar MH Al-Shamma, Najah R Hadi, Abdullah Elttayef Jasim, Ahmed Abdullah Ajrash Al-Khafaji, Ali M Janabi.

Chronic obstructive pulmonary disease (COPD) is a common clinical pathological disease characterized by rapid deterioration of lung function. Lack of effective treatment and complete understanding of mechanism of this disease lead to increased incidence of mortality and morbidity rate globally. The aim of this study is to determine the association of proinflammatory mediators with BODE index in patients with COPD. This study is a case control study including 87 COPD patients and 100 healthy individuals (as a control). FEV1 was assessed using spirometry to investigate pulmonary function. ELIZA technique was applied to examine the serum levels of IL-1B, IL-6 and TNF-a. There was significant increase in bothinterleukin-1 (IL-1) and interleukin-6 (IL-6) in COPD patients when compared to healthy individuals. However, the levels of tumor necrosis factor alpha (TNF-a) in COPD patients were not significantly different when compared to healthy individuals. FEV1/FVC ratio in COPD patients was significantly decreased when compared to healthy group. The pro inflammatory markers, IL-1 and IL-6, are more likely to be applicable in diagnosis and assessment of COPD. Additionally, BODE index is a suitable tool for assessment of severity of the disease.