Abstract

Patel DM, Jani RH, Patel CN

Unsaturated fatty acid vesicles (ufasomes) are suspensions of closed lipid bilayers that are composed of fatty acids, and their ionized species (soap) which are restricted to narrow pH range from 7 to 9. In ufasomes, fatty acid molecules are oriented in such a way that their hydrocarbon tails are directed toward the membrane interior and the carboxyl groups are in contact with water. Stable ufasome formulation critically depends on proper selection of fatty acid, amount of cholesterol, buffer, pH range, amount of lipoxygenase, and the presence of divalent cations. Recent innovations can provide opportunity to formulate ufasomes with tailorable features such as extension of pH range, insensitivity toward divalent cations, and enhancement of stability. This article describes method of ufasome preparation, key issues in ufasome manufacturing, recent innovations in ufasomes, dynamicity, stability, and microscopic characterization of ufasomes. Later part of this article deals with comparison of ufasomes with thoroughly studied liposomes.

How to Cite this Article

Pubmed Style Patel DM, Jani RH, Patel CN. Ufasomes: A Vesicular Drug Delivery. SRP. 2011; 2(2): 72-78. doi:10.4103/0975-8453.86290 Web Style Patel DM, Jani RH, Patel CN. Ufasomes: A Vesicular Drug Delivery. http://www.sysrevpharm.org/?mno=302644601 [Access: March 24, 2021]. doi:10.4103/0975-8453.86290 AMA (American Medical Association) Style Patel DM, Jani RH, Patel CN. Ufasomes: A Vesicular Drug Delivery. SRP. 2011; 2(2): 72-78. doi:10.4103/0975-8453.86290 Vancouver/ICMJE Style Patel DM, Jani RH, Patel CN. Ufasomes: A Vesicular Drug Delivery. SRP. (2011), [cited March 24, 2021]; 2(2): 72-78. doi:10.4103/0975-8453.86290 Harvard Style Patel DM, Jani RH, Patel CN (2011) Ufasomes: A Vesicular Drug Delivery. SRP, 2 (2), 72-78. doi:10.4103/0975-8453.86290 Turabian Style Patel DM, Jani RH, Patel CN. 2011. Ufasomes: A Vesicular Drug Delivery. Systematic Reviews in Pharmacy, 2 (2), 72-78. doi:10.4103/0975-8453.86290 Chicago Style Patel DM, Jani RH, Patel CN. "Ufasomes: A Vesicular Drug Delivery." Systematic Reviews in Pharmacy 2 (2011), 72-78. doi:10.4103/0975-8453.86290 MLA (The Modern Language Association) Style Patel DM, Jani RH, Patel CN. "Ufasomes: A Vesicular Drug Delivery." Systematic Reviews in Pharmacy 2.2 (2011), 72-78. Print. doi:10.4103/0975-8453.86290 APA (American Psychological Association) Style Patel DM, Jani RH, Patel CN (2011) Ufasomes: A Vesicular Drug Delivery. Systematic Reviews in Pharmacy, 2 (2), 72-78. doi:10.4103/0975-8453.86290<