Abstract

Ashima Sharma60612*

The description of a scarce brain disease, including its clinical and pathological features, was first made by Alois Alzheimer over 100 years ago. Earlier it was the concept of dementia only before the discovery of the first case of Alzheimer’s disease. Senile plaque formation was recognized as important in the early 1900s, and further investigation was conducted in the 1990s after the identification of beta-amyloid protein. Studies of the brains of both non-demented and demented individuals using neuropathological techniques demonstrated the progression from normal aging to Alzheimer-type dementia. To understand disease progression diagnostic methods developed over 100 years till now. Numerous obstacles still need to be overcome to provide a definite diagnosis of dementia. These include the inconsistency of initial symptoms and their similarity to other disorders, as well as the potential occurrence of mixed etiologies in certain cases. This review aims to summarize all the development of diagnostic methods over the years along with their use.