Ashish Kumar Mandal

Department of Pathology, Maulana Azad Medical College, New Delhi, India

Publications

  • Research   
    Importance of Sub-Cellular Localization of Caspase in Oro-Pharyngeal Carcinoma
    Author(s): Navneet Saini61093*, Rashmi Babbar61094 and Ashish Kumar Mandal61095

    Introduction: Caspase a family of cysteine protease plays an important role in programmed cell death. Caspase-3 and Caspase-8 are key regulators of apoptosis. Caspase-8 plays principal role in conveying signals from death ligand receptors to intracellular pro-apoptotic machinery. It was found exclusively in the cytoplasm, however, its presence has also been observed in other intracellular compartments. The role of Caspase-8 in tumor progression is contentious. Caspase-3 is a chief mediator of apoptosis and is cleaved to create an active form. The precursor form of Caspase-3 is localized in cytoplasm while active form is translocated to nucleus. Expression of active form of Cassspase-3 is studied in various forms of carcinomas but few reports regarding pro-caspase-3 are available. Some studies have also report the presence of inactive Caspase-3 in the nucleus.. Read More»
    DOI: 10.31858/0975-8453.14.8.530-534

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