Chris P Verschoor

Department of Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada

Publications

  • Research Article   
    Relative Antibody Mediated Protection against Influenza in Vaccinated Children
    Author(s): Charlotte Switzer47773*, Chris P Verschoor47774, Eleanor Pullenayegum47775, Pardeep Singh47776 and Mark Loeb47777

    Background: Adjuvanted influenza vaccine has been shown to elicit more robust vaccine immunogenicity, as measured by the Hemagglutination Inhibition (HAI) assay. Post-vaccination HAI titers are the accepted correlate of protection against influenza. However, the proportion of relative vaccine protection in adjuvanted vaccines that is mediated by increased HAI titers has not been investigated. Methods: A cluster randomized controlled trial of influenza vaccines in Canadian Hutterite colonies was conducted from the 2016-2017 to the 2018-2019 influenza season. Children were vaccinated with either Quadrivalent Inactivated Influenza Vaccine (QIV), or the MF59 adjuvanted trivalent influenza vaccine (aTIV). Sera were collected prior to and four weeks after vaccination, and HAI titers against A/H3N2 vaccine antigens were measured. We tested for diff.. Read More»
    DOI: 10.31858/0975-8453.13.10.847-854

    Abstract HTML PDF