Eliton Chivandi
Department of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaPublications
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Research Article
Ficus thonningii Stem Bark Extracts Prevent High Fructose Diet Induced Increased Plasma Triglyceride Concentration, Hepatic Steatosis and Inflammation in Growing Sprague-Dawley Rats
Author(s): Eliton Chivandi39691*, Yvonne Mhosva39692, Trevor Nyakudya39693 and Pilani Nkomozepi39694
Background: Ficus thonningii extracts exhibit hypoglycaemic, hypolipidaemic and antioxidant activitiese investigated the potential of methanolic F. thonningii stem-bark extracts (MEFT) to protect growing Sprague-Dawley (SD) against high-fructose diet-induced Metabolic Derangements (MD) in a model mimicking childreenic diets. Methods: Eighty (40 males; 40 females) 21-days old SD rat pups were randomly allocated to and administered, for 8 weeks, five treatment regimens: 1-standard rat chow (SC)+water (PW), 2-SC+20% (w/v) fructose solution (FS), 3-SC+FS+fenofibrate at 100 mg/kg bwt/ day, 4-SC+FS+low dose MEFT (LD; 50 mg/kg bwt/day) and 5-SC+FS+high dose MEFT (HD; 500 mg/kg bwt/ day). Body weight, glucose load tolerance, fasting blood glucose and triglyceride, plasma insulin concentration, sensitivity to insulin, liver mass and.. Read More»
DOI: 10.31858/0975-8453.13.3.205-212
Abstract
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