Farzaneh Sabouni
Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, IranPublications
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Research Article
Effect of Echinacea purpurea?s Extract on Gastric Cancer Cell (AGS) Growth, Migration, Colony Formation, Tube Formation, Apoptosis, and VEGF-A Gene Expression
Author(s): Azar Sadeghi49243, Fatemeh Moradian49244*, Farzaneh Sabouni49245 and Forough Sanjarian49246
Echinacea purpurea extract, one of the main compounds of which is caffeic acid, has anti-cancer and anti-angiogenic properties. In the present study, the anticancer effect of E. purpurea’s extract was investigated on the growth of gastric cancer cell line AGS, induction of apoptosis and inhibition of cell migration, tube formation and colony formation as well as the expression level of the VEGF-A gene. E. purpurea’s extract was extracted using a Soxhlet device and HPLC chromatography was used to confirm the presence of caffeic acid in the extract. The result showed that the cell viability percentage as well as the formation of colonies in AGS cancer cells after treatment of the plant extract were reduced in a dosedependent manner. The orange-red fluorescence after treatment was increased indicating the emergence of apoptosis. The assessment of th.. Read More»
DOI: 10.31858/0975-8453.13.12.870-881
Abstract
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