Ghaleb Adwan
Department of Process Engineering, Height School of Technology, Sidi Mohammed Ben Abdallah University, Fez, MoroccoPublications
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Research Article
Heterocylcic Based Curcumin: Design, Synthesis and Anticancer Efficacy against HeLa Cells
Author(s): Rana Al-Kerm40101, Rola Al-Kerm40102, Othman Hamed40103*, Ashraf Swaft40104, Mohammad Qneibi40105, Avni Berisha40106, Omar Dagdage40107 and Ghaleb Adwan40109
Developing a new effective anticancer agent becomes an urgent need to overcome of current drug-resistance. In this study, we demonstrated that curcumin with heterocyclic moiety can function as an anticancer agent in a human. A new series of curcumin-based benzodiazepines, diazepines and diazoles were prepared using a simple one pot process. The process involved a condensation reaction of curcumin with various 1,2 diamino compounds and hydrazine. The structures of the prepared heterocycles were identified by the spectroscopic methods Fourier-Transform Infrared Spectroscopy (FT-IR), 1H NMR (Proton Nuclear Magnetic Resonance), and 13C NMR. The in vitro anticancer activities of the synthesized curcumin-based heterocycles against HeLa cancer cells were evaluated by the 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. The viability of.. Read More»
DOI: 10.31858/0975-8453.13.8.499-507
Abstract
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