Kazuo Mihara
Department of Neuropsychiatry, University of the Ryukyus, Nishihara, JapanPublications
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Research
UGT2B7 372A>G Polymorphism is related to a Therapeutic Response to Lamotrigine Augmentation Therapy in Depressed Patients Who Did Not Respond to Adequate Treatment: A Preliminary Study
Author(s): Shoko Kagawa36697, Kazuo Mihara36698*, Takeshi Suzuki36699, Goyo Nagai36700, Akifumi Nakamura36704, Kenji Nemoto36706 and Tsuyoshi Kondo36708
Purpose: Lamotrigine is mainly metabolized by UGT1A4 and UGT2B7, both of which are expressed in the blood-brain barrier. Polymorphisms of said UDPglucuronosyltransferases, (UGTs) that affect enzyme activities have been reported. This study investigated the relationship between these polymorphisms and its therapeutic effect in 55 depressed patients who did not respond to adequate treatment during an 8-week treatment of lamotrigine augmentation using an open-study design. Patients and Methods: The subjects were 55 depressed patients who had already shown insufficientc response to at least 3 psychotropics including antidepressants, mood stabilizers, and atypical antipsychotics. The diagnoses were major depressive disorder (n=22), bipolar I disorder (n=9), and bipolar II disorder (n=24). The final doses of lamotrigine .. Read More»
DOI: 10.31858/0975-8453.13.4.261-264
Abstract
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