Munjaji Balasaheb Pitale

Department of Pharmaceutics, Bombay College of Pharmacy, Mumbai, Maharashtra, India

Publications

  • Research Article   
    Mucoadhesive Nanostructured Lipid Carriers Based Gel to Treat Vulvovaginal Candidiasis
    Author(s): Shubhangi Aher73553* and Munjaji Balasaheb Pitale73552

    This study focused on the development and characterization of Fluconazole (FLZ) loaded Nano Lipid Carriers (NLCs) based mucoadhesive gel to increase retention time on applied region to treat Vulvovaginal Candidiasis (VVC). FLZ is administered orally or topically to treat VVC, oral route has a cardiac adverse effect known as FLZ-induced Torsade de pointes. Patients with heart conditions and pregnant women are at risk of receiving orally FLZ, hence topical drug delivery is preferable. Nanostructured lipid carriers were formed in this study using a solvent-diffusion approach followed by high-speed homogenization. For the development of nanostructured lipid carriers Generally Recognized As Safe (GRAS) excipients were selected and optimised such as Compritol-888-ATO, oleic acid and tween-80. NLCs were characterised by particle size, Polydispersity Index (PDI), zeta potential, entrapment ef.. Read More»
    DOI: 10.31858/0975-8453.15.6.194-204

    Abstract HTML PDF