Pedro Abreu González
Department of Human Physiology, University of La Laguna, San Cristóbal de La Laguna, SpainPublications
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Research Article
Oxidative Stress and Quality of Life in Severe COPD in Stable Phase
Author(s): Juan Abreu González60605*, Pedro Abreu González60606, Alejandro Jiménez Sosa60608, Ciro Casanova Macarios60609, De Torres Tajés60610 and Martin García60611
Objective: Oxidative Stress (OS) is a pathogenic mechanism present in Chronic Obstructive Pulmonary Disease (COPD), with a systemic effect and which can alter the quality of life of patients. The aim of this study is to study the relationship between OE and quality of life in patients with stable COPD. Methods: Seventy-six subjects were studied, 54 with COPD and 22 controls. The amount of malondialdehyde (MDA) in serum (nmol/mL) and induced sputum (nmol/mg protein) were measured as markers of systemic and bronchial OE, respectively. In addition, quality of life was measured using the St. George’s questionnaire, which is specific for COPD patients. Results: Patients with COPD presented higher serum MDA levels than controls (2.98 ± 0.03 nmol/mL vs. 1.2 ± 0.03 nmol/mL, p<0.001 respectively). An .. Read More»
DOI: 10.31858/0975-8453.14.7.452-456
Abstract
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