Pratik Vijay Malvade

Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Maharashtra, India

Publications

  • Research Article   
    Metabolism of Arsenic in Human by AS3MT Gene
    Author(s): Pratik Vijay Malvade47782*, Mayur S Bhosale47783, Sayli R Chavan47784 and Dhanashri B Bhagat47785

    The AS3MTM may be the most significant protein for the methylation of chemical elements species. The transfer of methyl radical from S-adenosyl-L-methionine (AdoMet) to powerfulness arsenical (AsIII) is catalyzed by the AS3MTM that is critical for arsenic metabolism in humans. Since the AS3MTM genetic polymorphism is linked to arsenic resistance, the association between the Single Ester Polymorphism (SNP) and AS3MTM inorganic arsenic (iAs) metabolism is being studied. Additionally, we tend to compared chemical action properties of recombinant human AS3MTM and AS3MTM/M287T. In reaction S-adenosyl methionine, arsenite, or methyl arsonous acid (MAsIII) as substrates and endogenous reductants, together with Glutathione (GSH), a Thioredoxin enzyme (TR) system and Tris (2-carboxyethyl) Pesticide complex (TCEP). By v.. Read More»
    DOI: : 10.31858/0975-8453.13.12.819-825

    Abstract HTML PDF