Sikrit Denariyakoon
The Queen Sirikit Center for Breast Cancer, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, ThailandPublications
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Review Article
Box A of HMGB1 Producing DNA Gaps: A Remedy for the DNA Protection and Rejuvenation Effects in Age- and DNA Damage-Associated Diseases
Author(s): Rathasapa Patarat53941, Wilunplus Khumsri53942, Sikrit Denariyakoon53943 and Apiwat Mutirangura53944*
The world is becoming an aging society at an unprecedented pace, and the health and socioeconomic burden from age-associated diseases continue to rise. Age-associated conditions are causing physical and functional deterioration toward organs failure. Understanding the aging process is the key to developing therapeutic protocols for many Non-Communicable Diseases (NCDs). Recently, persistent DNA damage has been proposed to drive the human aging process. However, the underlying mechanisms of the DNA damage accumulation in the elderly have not been clearly understood. Our research showed the DNA protective role of the naturally occurring DNA gaps called Youth-associated genome-stabilizing DNA gaps (Youth-DNA-gaps). The reduction of the DNA gaps in the elderly accumulates DNA damage. Box A of HMGB1 protein acts as molecular scissors producing Youth-DNA-gaps. Introducing the Box A expressi.. Read More»
DOI: 10.31858/0975-8453.14.3.164-176
Abstract
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