Xiaobu Lan
Department of Pharmacy, The Fifth Affiliated Hospital of Guangxi Medical University, Guangxi Province, ChinaPublications
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Research Article
Network Pharmacology and Experimental Validation Reveal the Anti-Inflammatory Effects of Schefflera octophylla via Inhibition of the PI3K-AKT Pathway
Author(s): Xiaoqin Zhou75304, Bin Yang75305, Yao Liang75306 and Xiaobu Lan75307*
Background: Ethnopharmacological relevance shows that Schefflera octophylla (Lour.) Harms is an indigenous plant and traditional Chinese medicine. WaiGan mixture II, which is a complex herbal preparation contains Schefflera octophylla as the main herb and is commonly employed in clinical practice to treat conditions associated with wind-heat colds, such as the resolution of heat, toxins and alleviation of throat symptoms. Although these uses of Schefflera octophylla highlight its potential as an anti-inflammatory agent, its efficacy and underlying mechanisms remain to be thoroughly explored. As traditional Chinese medicines contain a multitude of ingredients, it can be challenging to determine the specific small molecular compounds responsible for their medicinal effects. Here, we aim to identify the active anti-inflammat.. Read More»
DOI: 10.31858/0975-8453.15.10.311-320
Abstract
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