Yahua Bi

Department of Tourism and Convention, Pusan National University, Busan, South Korea

Publications

  • Research Article   
    Deletion of TET1 in Mice with Impaired Prefrontal Cortex Functions by Activating the NGF/TRKA Signaling Pathway
    Author(s): Yanhua Bi57746*, Hui Gao57747 and Yahua Bi57748

    TET1 (Ten-eleven translocation methylcytosine dioxygenase 1) is the enzyme methylcytosine dioxygenase of DNA demethylation in the nervous system. TET1 controls and mediates gene transcription, memory formation, and extinction. However, little is known about TET1 in Prefrontal Cortex (PFC) functions especially in the medial Prefrontal Cortex (mPFC), which controls cortex flexibility and emotional reactivity in the Central Nervous System (CNS). This study conducted behavioral tests including an open field test, sociability and social novelty preference tests, social dominance, and Prepulse Inhibition (PPI) test to examine brain functions, especially PFC functions after the deletion of TET1. The mPFC from TET1 KO mice and WT adult mice was analyzed using Quantitative Reverse-Transcriptio.. Read More»
    DOI: 10.31858/0975-8453.14.5.315-324

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